Additive Layer Manufacturing
A novel design-through-manufacture approach to Transparent Face Orthosis for deployed medical environments
Imperial College London
This project aims to demonstrate the rapid design and manufacture of a custom Transparent Face Orthosis (TFO) using automated design processes and 3D printing for manufacture in deployed medical care scenarios.
Start Date: 08 Feb 2021 Amount awarded: £60,990 Research Team: C. Myant , T. Coward , M Khan   Dyson School of Design Engineering, Imperial College London,  Maxillofacial and Craniofacial Rehabilitation, King College London,  Trauma Surgery, Brighton and Sussex University Hospitals.
Handheld Electrospinning of Antimicrobial Laminar Structures (HEALS) for simultaneous fabrication and application of micro and nanofibrous wound dressings
The aim is to overcome challenges in the delivery of electrospun materials and translate electrospinning techniques to deployed medical settings, a more direct approach is proposed.
Start Date: 15 Mar 2021 Amount awarded: £62,328 Research Team C. Wright , L. Burke , J. Osborn   College of Engineering, Swansea University,  Early Career Researcher,  Wiltshire Primary Care Network Additional Support ProColl Ltd
Personalised wound healing devices: using new additive manufacturing capabilities for previously impossible 3D geometries and functionality
Loughborough University (LU)
The study uses pharmaceutical materials and demonstrates novel time-release profiles for multi- layered active pharmaceutical ingredients. With support from medical and deployed operations experts, a range of alternative research extensions for wound treatment will be evaluated, including embedded sensors, graded porosity to allow in-situ washing, and nanofibre-bundle printing to tailor absorbency.
Principle Investigator: Dr. Andy Gleedall
Cell & Tissue Manufacturing
Proof-of-concept of long-term storage of functional extra-cellular vesicles for application in accelerated soft-tissue and fracture healing
The aim is to standardise an effective storage method of extra–cellular vesicles (EVs) from mesenchymal–stem–cells for use in enhancing fracture and soft–tissue healing, as part of a wider established manufacturing process.
Start Date:15 Apr 2021 Amount awarded: £62,582 Research Team: N. Wragg , D. Player , N R. Forsyth .  Bioengineering, Keele University,  Musculoskeletal Bioengineering, University College London,  Stem Cell Biology, Keele University.
Combining Orthobiologics, Antimicrobial and Angiogenic Properties for Rapid Treatment of Bone Repair in Deployed Settings
University of Nottingham
The aim of this project will be to produce unique PBG formulations by enhancing them with antibacterial and angiogenic properties by adding copper ions. Furthermore, we aim to incorporate lyophilised EVs within these injectable porous microspheres, to address their use in potentially contaminated environments to enable rapid tissue repair and regeneration, thereby delivering novel ‘Orthobiologics’ based treatments.
Start Date: 08 Mar 2021 Amount awarded: £47,806 Research Team I. Ahmed , O Davies   University of Nottingham,  Molecular & Regenerative Biomedicine, Loughborough University. Additional Support Lonza – Pharma & Biotech
Point-of-care of skin wounds via automated therapeutic layer-by-layer coatings
This feasibility study aims to develop a device for the treatment of skin burns and trauma injuries by administrating therapeutic skin coatings to minimise infections and reduce pain. The portable layer-by-layer skin device has no need for specialised skills or knowledge by the end user and can be easily sterilised, delivering therapeutic biomaterials and drug combinations to patients’ wound-specific needs, providing prompt point-of-care and wound management.
Principal Investigator : Dr Ana Ferreira-Duarte and Dr Piergiorgio Gentile
Cryopreservation and resuscitation of regeneratively primed skeletal ‘myo-grafts’ for autologous soft tissue repair in deployed surgical environments
This research addresses the need for highly technical biological facilities, and ways to overcome the time taken to create tissues that are maximised in regenerative capacity. By developing a manufacturing process that overcomes the logistical challenges in the implementation of regenerative cellular ‘myo-grafts,’ patient derived musculoskeletal tissue can be manufactured, regeneratively primed and preserved ‘offline,’ to be stored and deployed in anticipation of future trauma.
Principal Investigator: Dr. Andrew Capel
Ultrafast 3D printed personalised wound fillings for immediate stabilization and regeneration of soft tissues
Additive manufacturing technologies have demonstrated efficacy in fabricating bespoke structures and versatility in 3D printing of several tissues. This project explores personalised wound filling technology that can be rapidly shaped and enhance tissue formation. These filings will be a proof-of-concept for using this innovative technology in deployed situations where time and efficiency play a critical role.
Principal Investigator: Dr Yingfeng He
AMPlify: Redistributed Manufacturing Of Antimicrobial Peptides for Wound Care
The aim is to develop AMPlify, a proof-of principle of a cold-chain-free biological RDM system that is stable for 3 months at 40C and can manufacture single-doses (2 ug/ml) of the antimicrobial peptide (AMP) RP557, which has shown promise for treatment of infected wounds (Woodburn et al., 2019).
Start Date: 30 Apr 2021 Amount awarded: £68,622 Research Team J. Molloy , L. Hall , C. Gandini   Department of Chemical Engineering and Biotechnology, Cambridge University. Additional Support Glia Project Field Ready
Decentralised Manufacture of Combi-pills at Point of Care
University of East Anglia
The aim is to establish proof-of-concept data for a hybrid 3DP platform for decentralised point-of-care manufacturing of combi-pills that will enable the team to apply for larger funding to further develop the technology towards bespoke GMP-grade hardware, digital process control and user-friendly digital combi-pill design tools.
Start Date: 12 Apr 2021 Amount awarded: £70,862 Research Team S. Qi , A Gleadall  R. Bibb   School of Pharmacy, University of East Anglia,  Additive Manufacturing in the Wolfson School of Mechanical, Electrical & Manufacturing Engineering, Loughborough University,  School of Design & Creative Arts, Loughborough University. Additional Support Cellink Life Sciences
The on-demand manufacture of potable & sterile water for emergency medical, humanitarian & healthcare applications using electrochemical activation production technologies
This collaborative project aims to develop, prototype, test and evaluate technologies for mobile, ‘on-demand’ production and manufacture of potable and sterile water for the delivery of medical care in resource constrained environments.
Prof. Darren Reynolds