Our Projects

Additive Layer Manufacturing

A novel design-through-manufacture approach to Transparent Face Orthosis for deployed medical environments
Organisation
Imperial College London
Aims:
This project aims to demonstrate the rapid design and manufacture of a custom Transparent Face Orthosis (TFO) using automated design processes and 3D printing for manufacture in deployed medical care scenarios.
Key Information
Start Date: 08 Feb 2021 Amount awarded: £60,990 Research Team: C. Myant [1], T. Coward [2], M Khan [3] [1] Dyson School of Design Engineering, Imperial College London, [2] Maxillofacial and Craniofacial Rehabilitation, King College London, [3] Trauma Surgery, Brighton and Sussex University Hospitals.
Previous
Next
Handheld Electrospinning of Antimicrobial Laminar Structures (HEALS) for simultaneous fabrication and application of micro and nanofibrous wound dressings
Organisation
Swansea University
Aims:
The aim is to overcome challenges in the delivery of electrospun materials and translate electrospinning techniques to deployed medical settings, a more direct approach is proposed.
Key Information
Start Date: 15 Mar 2021 Amount awarded: £62,328 Research Team C. Wright [1], L. Burke [2], J. Osborn [3] [1] College of Engineering, Swansea University, [2] Early Career Researcher, [3] Wiltshire Primary Care Network Additional Support ProColl Ltd
Previous
Next
Personalised wound healing devices: using new additive manufacturing capabilities for previously impossible 3D geometries and functionality
Organisation
Loughborough University (LU)
The study uses pharmaceutical materials and demonstrates novel time-release profiles for multi- layered active pharmaceutical ingredients. With support from medical and deployed operations experts, a range of alternative research extensions for wound treatment will be evaluated, including embedded sensors, graded porosity to allow in-situ washing, and nanofibre-bundle printing to tailor absorbency.
Principle Investigator: Dr. Andy Gleedall
Previous
Next

Cell & Tissue Manufacturing

Proof-of-concept of long-term storage of functional extra-cellular vesicles for application in accelerated soft-tissue and fracture healing
Organisation
Keele University
Aims:
The aim is to standardise an effective storage method of extra–cellular vesicles (EVs) from mesenchymal–stem–cells for use in enhancing fracture and soft–tissue healing, as part of a wider established manufacturing process.
Key Information
Start Date:15 Apr 2021 Amount awarded: £62,582 Research Team: N. Wragg [1], D. Player [2], N R. Forsyth [3]. [1] Bioengineering, Keele University, [2] Musculoskeletal Bioengineering, University College London, [3] Stem Cell Biology, Keele University.
Previous
Next
Combining Orthobiologics, Antimicrobial and Angiogenic Properties for Rapid Treatment of Bone Repair in Deployed Settings
Organisation
University of Nottingham
Aims:
The aim of this project will be to produce unique PBG formulations by enhancing them with antibacterial and angiogenic properties by adding copper ions. Furthermore, we aim to incorporate lyophilised EVs within these injectable porous microspheres, to address their use in potentially contaminated environments to enable rapid tissue repair and regeneration, thereby delivering novel ‘Orthobiologics’ based treatments.
Key Information
Start Date: 08 Mar 2021 Amount awarded: £47,806 Research Team I. Ahmed [1], O Davies [2] [1] University of Nottingham, [2] Molecular & Regenerative Biomedicine, Loughborough University. Additional Support Lonza – Pharma & Biotech
Previous
Next
Point-of-care of skin wounds via automated therapeutic layer-by-layer coatings
Organisation
Newcastle University
This feasibility study aims to develop a device for the treatment of skin burns and trauma injuries by administrating therapeutic skin coatings to minimise infections and reduce pain. The portable layer-by-layer skin device has no need for specialised skills or knowledge by the end user and can be easily sterilised, delivering therapeutic biomaterials and drug combinations to patients’ wound-specific needs, providing prompt point-of-care and wound management.
Principal Investigator : Dr Ana Ferreira-Duarte and Dr Piergiorgio Gentile
Previous
Next
Cryopreservation and resuscitation of regeneratively primed skeletal ‘myo-grafts’ for autologous soft tissue repair in deployed surgical environments
Organisation
Loughborough University
This research addresses the need for highly technical biological facilities, and ways to overcome the time taken to create tissues that are maximised in regenerative capacity. By developing a manufacturing process that overcomes the logistical challenges in the implementation of regenerative cellular ‘myo-grafts,’ patient derived musculoskeletal tissue can be manufactured, regeneratively primed and preserved ‘offline,’ to be stored and deployed in anticipation of future trauma.
Principal Investigator: Dr. Andrew Capel
Previous
Next
Ultrafast 3D printed personalised wound fillings for immediate stabilization and regeneration of soft tissues
Organisation
Nottingham University
Additive manufacturing technologies have demonstrated efficacy in fabricating bespoke structures and versatility in 3D printing of several tissues. This project explores personalised wound filling technology that can be rapidly shaped and enhance tissue formation. These filings will be a proof-of-concept for using this innovative technology in deployed situations where time and efficiency play a critical role.
Principal Investigator: Dr Yingfeng He
Previous
Next

Pharmaceutical Manufacturing

AMPlify: Redistributed Manufacturing Of Antimicrobial Peptides for Wound Care
Organisation
Cambridge University
Aims:
The aim is to develop AMPlify, a proof-of principle of a cold-chain-free biological RDM system that is stable for 3 months at 40C and can manufacture single-doses (2 ug/ml) of the antimicrobial peptide (AMP) RP557, which has shown promise for treatment of infected wounds (Woodburn et al., 2019).
Key Information
Start Date: 30 Apr 2021 Amount awarded: £68,622 Research Team J. Molloy [1], L. Hall [1], C. Gandini [1] [1] Department of Chemical Engineering and Biotechnology, Cambridge University. Additional Support Glia Project Field Ready
Previous
Next
Decentralised Manufacture of Combi-pills at Point of Care
Organisation
University of East Anglia
Aims:
The aim is to establish proof-of-concept data for a hybrid 3DP platform for decentralised point-of-care manufacturing of combi-pills that will enable the team to apply for larger funding to further develop the technology towards bespoke GMP-grade hardware, digital process control and user-friendly digital combi-pill design tools.
Key Information
Start Date: 12 Apr 2021 Amount awarded: £70,862 Research Team S. Qi [1], A Gleadall [2] R. Bibb [3] [1] School of Pharmacy, University of East Anglia, [2] Additive Manufacturing in the Wolfson School of Mechanical, Electrical & Manufacturing Engineering, Loughborough University, [3] School of Design & Creative Arts, Loughborough University. Additional Support Cellink Life Sciences
Previous
Next

Clinical Fluids

The on-demand manufacture of potable & sterile water for emergency medical, humanitarian & healthcare applications using electrochemical activation production technologies
Organisation
UWE
This collaborative project aims to develop, prototype, test and evaluate technologies for mobile, ‘on-demand’ production and manufacture of potable and sterile water for the delivery of medical care in resource constrained environments.
Prof. Darren Reynolds
Previous
Next