RiHN
Projects
Additive Layer Manufacturing
Digital design and manufacturing of personalised prosthetic socket on-demand: Technical validation in laboratory
Loughborough University
This project proposes to develop an adaptive, modular prosthesis socket on-demand with remote assessment and manufacturing capability by using a combination of digital design-to-manufacturing workflow with intuitive, expert-assisted graphical user interface(GUI)and deployable additive manufacturing(AM) for both mobility impaired civilian and military personnel.
Key Information
Start Date: 26 Apr 2021
Amount awarded: £75,547
Research Team
S. Li [1], T. Allen [2], R J. O’Connor [3]
[1]Mechanics of Biomaterials, Loughborough University, [2] Mechanical Engineering, Manchester Metropolitan University. [3] Rehabilitation Medicine, University of Leeds.
Additional Support
Laser Lines Ltd – R. Hoy, C. Parsons [5], A. Paterson [6]
[5] Design Prosthetics Ltd, [6] Industrial Design and Technology, Loughborough University
A novel design-through-manufacture approach to Transparent Face Orthosis for deployed medical environments
Imperial College London
This project aims to demonstrate the rapid design and manufacture of a custom Transparent Face Orthosis (TFO) using automated design processes and 3D printing for manufacture in deployed medical care scenarios.
Key Information
Start Date: 08 Feb 2021
Amount awarded: £60,990
Research Team
C. Myant [1], T. Coward [2], M Khan [3]
[1] Dyson School of Design Engineering, Imperial College London, [2] Maxillofacial and Craniofacial Rehabilitation, King College London, [3] Trauma Surgery, Brighton and Sussex University Hospitals.
Handheld Electrospinning of Antimicrobial Laminar Structures (HEALS) for simultaneous fabrication and application of micro and nanofibrous wound dressings
Swansea University
The aim is to overcome challenges in the delivery of electrospun materials and translate electrospinning techniques to deployed medical settings, a more direct approach is proposed. The Handheld Electrospinning of Antimicrobial Laminar Structures (HEALS)project aims to miniaturise equipment and automate processing variables to deposit electro spun materials directly onto the wound bed.
Key Information
Start Date: 15 Mar 2021
Amount awarded: £62,328
Research Team
C. Wright [1], L. Burke [2], J. Osborn [3]
[1] College of Engineering, Swansea University, [2] Early Career Researcher, [3] Wiltshire Primary Care Network
Additional Support
ProColl Ltd
Cell & Tissue Manufacturing
Proof-of-concept of long-term storage of functional extra-cellular vesicles for application in accelerated soft-tissue and fracture healing
Keele University
The aim is to standardise an effective storage method of extra–cellular vesicles (EVs) from mesenchymal–stem–cells for use in enhancing fracture and soft–tissue healing, as part of a wider established manufacturing process.
Key Information
Start Date:15 Apr 2021
Amount awarded: £62,582
Research Team
N. Wragg [1], D. Player [2], N R. Forsyth [3].
[1] Bioengineering, Keele University, [2] Musculoskeletal Bioengineering, University College London, [3] Stem Cell Biology, Keele University.
Combining Orthobiologics, Antimicrobial and Angiogenic Properties for Rapid Treatment of Bone Repair in Deployed Settings
University of Nottingham
The aim of this project will be to produce unique PBG formulations by enhancing them with antibacterial and angiogenic properties by adding copper ions. Furthermore, we aim to incorporate lyophilised EVs within these injectable porous microspheres, to address their use in potentially contaminated environments to enable rapid tissue repair and regeneration, thereby delivering novel ‘Orthobiologics’ based treatments.
Key Information
Start Date: 08 Mar 2021
Amount awarded: £47,806
Research Team
I. Ahmed [1], O Davies [2]
[1] University of Nottingham, [2] Molecular & Regenerative Biomedicine, Loughborough University.
Additional Support
Lonza – Pharma & Biotech
Pharmaceutical Manufacturing
Decentralised manufacture of combi-pills at point of care
University of East Anglia
The aim is to establish proof-of-concept data for a hybrid 3DP platform for decentralised point-of-care manufacturing of combi-pills that will enable the team to apply for larger funding to further develop the technology towards bespoke GMP-grade hardware, digital process control and user-friendly digital combi-pill design tools.
Key Information
Start Date: 12 Apr 2021
Amount awarded: £70,862
Research Team
S. Qi [1], A Gleadall [2] R. Bibb [3]
[1] School of Pharmacy, University of East Anglia, [2] Additive Manufacturing in the Wolfson School of Mechanical, Electrical & Manufacturing Engineering, Loughborough University, [3] School of Design & Creative Arts, Loughborough University.
Additional Support
Cellink Life Sciences
AmorFlow: amorphous pharmaceuticals through continuous manufacturing in flow
Kings College London
The proposed project aims to demonstrate a world first attempt to produce a ready-to-use, precise formulation of analgesics on-demand, in a format suitable for redistributed manufacturing and deployed operations, using novel manufacturing techniques based on flow technologies.
Key Information
Start Date: 19 Apr 2021
Amount awarded: £89,776
Research Team
[1] Professor H. Makatsoris [2]
Professor C. Frampton
[1] Department of Engineering, King’s College London, [2] Department of Engineering, Brunel University
Additional Support
Centillion Technology Ltd
AMPlify: redistributed manufacturing of antimicrobial peptides for wound care
University of Cambridge
The aim is to develop AMPlify, a proof-of principle of a cold-chain-free biological RDM system that is stable for 3 months at 40C and can manufacture single-doses (2 ug/ml) of the antimicrobial peptide (AMP) RP557, which has shown promise for treatment of infected wounds (Woodburn et al., 2019).
Key Information
Start Date: 30 Apr 2021
Amount awarded: £68,622
Research Team
J. Molloy [1], L. Hall [1], C. Gandini [1]
[1] Department of Chemical Engineering and Biotechnology, Cambridge University.
Additional Support
Glia Project
Field Ready